Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA‐DRB1 region in Iranian population
Identifieur interne : 000505 ( Main/Exploration ); précédent : 000504; suivant : 000506Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA‐DRB1 region in Iranian population
Auteurs : S. Vallian [Iran] ; M. Tajadod [Iran] ; Z. Hojati [Iran]Source :
- Tissue Antigens [ 0001-2815 ] ; 2010-07.
English descriptors
Abstract
Genomewide screen analysis has shown the close association of the human leukocyte antigen (HLA)‐DRB1 region with susceptibility to multiple sclerosis and a number of autoimmune diseases. Using bioinformatics software, several potential short tandem repeat (STR) markers have been introduced in this region in the major histocompatibility complex data base (dbMHC). In this study, the identity and characteristics of two putative STR markers, D6S2879 and D6S2806, in this region were examined in Iranian population. The loci were genotyped in 85 individuals using polymerase chain reaction followed by polyacrylamide gel electrophoresis and sequencing. Analysis of the allelic frequency showed the presence of six and four alleles for D6S2806 and D6S2879, respectively. Analysis of deviations from Hardy–Weinberg equilibrium (HWE) showed that D6S2806 was in equilibrium (P > 0.05). However, the D6S2879 locus showed a significant deviation from HWE (P < 0.05). Therefore, the D6S2806 locus could be suggested as a marker for linkage analysis and disease‐susceptibility investigations in the MHC‐DRB1 gene region.
Url:
DOI: 10.1111/j.1399-0039.2010.01467.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000362
- to stream Istex, to step Curation: 000361
- to stream Istex, to step Checkpoint: 000255
- to stream Main, to step Merge: 000505
- to stream Main, to step Curation: 000505
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA‐DRB1 region in Iranian population</title><author><name sortKey="Vallian, S" sort="Vallian, S" uniqKey="Vallian S" first="S." last="Vallian">S. Vallian</name></author><author><name sortKey="Tajadod, M" sort="Tajadod, M" uniqKey="Tajadod M" first="M." last="Tajadod">M. Tajadod</name></author><author><name sortKey="Hojati, Z" sort="Hojati, Z" uniqKey="Hojati Z" first="Z." last="Hojati">Z. Hojati</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BF68D3AC87359E4056477692E7E472B0263B04B3</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1399-0039.2010.01467.x</idno><idno type="url">https://api.istex.fr/document/BF68D3AC87359E4056477692E7E472B0263B04B3/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000362</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000362</idno><idno type="wicri:Area/Istex/Curation">000361</idno><idno type="wicri:Area/Istex/Checkpoint">000255</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000255</idno><idno type="wicri:doubleKey">0001-2815:2010:Vallian S:characterization:of:d</idno><idno type="wicri:Area/Main/Merge">000505</idno><idno type="wicri:Area/Main/Curation">000505</idno><idno type="wicri:Area/Main/Exploration">000505</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA‐DRB1 region in Iranian population</title><author><name sortKey="Vallian, S" sort="Vallian, S" uniqKey="Vallian S" first="S." last="Vallian">S. Vallian</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Iran</country></affiliation></author><author><name sortKey="Tajadod, M" sort="Tajadod, M" uniqKey="Tajadod M" first="M." last="Tajadod">M. Tajadod</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Hojati, Z" sort="Hojati, Z" uniqKey="Hojati Z" first="Z." last="Hojati">Z. Hojati</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Tissue Antigens</title><idno type="ISSN">0001-2815</idno><idno type="eISSN">1399-0039</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-07">2010-07</date><biblScope unit="volume">76</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="60">60</biblScope><biblScope unit="page" to="63">63</biblScope></imprint><idno type="ISSN">0001-2815</idno></series><idno type="istex">BF68D3AC87359E4056477692E7E472B0263B04B3</idno><idno type="DOI">10.1111/j.1399-0039.2010.01467.x</idno><idno type="ArticleID">TAN1467</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-2815</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>D6S2806</term><term>D6S2879</term><term>Iranian population</term><term>human leukocyte antigen‐DRB1</term><term>short tandem repeat</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genomewide screen analysis has shown the close association of the human leukocyte antigen (HLA)‐DRB1 region with susceptibility to multiple sclerosis and a number of autoimmune diseases. Using bioinformatics software, several potential short tandem repeat (STR) markers have been introduced in this region in the major histocompatibility complex data base (dbMHC). In this study, the identity and characteristics of two putative STR markers, D6S2879 and D6S2806, in this region were examined in Iranian population. The loci were genotyped in 85 individuals using polymerase chain reaction followed by polyacrylamide gel electrophoresis and sequencing. Analysis of the allelic frequency showed the presence of six and four alleles for D6S2806 and D6S2879, respectively. Analysis of deviations from Hardy–Weinberg equilibrium (HWE) showed that D6S2806 was in equilibrium (P > 0.05). However, the D6S2879 locus showed a significant deviation from HWE (P < 0.05). Therefore, the D6S2806 locus could be suggested as a marker for linkage analysis and disease‐susceptibility investigations in the MHC‐DRB1 gene region.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Vallian, S" sort="Vallian, S" uniqKey="Vallian S" first="S." last="Vallian">S. Vallian</name></noRegion><name sortKey="Hojati, Z" sort="Hojati, Z" uniqKey="Hojati Z" first="Z." last="Hojati">Z. Hojati</name><name sortKey="Tajadod, M" sort="Tajadod, M" uniqKey="Tajadod M" first="M." last="Tajadod">M. Tajadod</name><name sortKey="Vallian, S" sort="Vallian, S" uniqKey="Vallian S" first="S." last="Vallian">S. Vallian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/RenardV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000505 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000505 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= RenardV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:BF68D3AC87359E4056477692E7E472B0263B04B3
|texte= Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA‐DRB1 region in Iranian population
}}
| This area was generated with Dilib version V0.6.27. |  |